Although heightened pain sensitivity is a hallmark of FM, little is known about the genetic and other factors that contribute to this abnormality. Gabapentin has not been approved by the Food and Drug Administration FDA for the treatment of fibromyalgia, although some doctors may prescribe it off-label for such use. Thank you i am sore no more! Abstract Background Fibromyalgia syndrome FMSa chronic musculoskeletal condition characterized by diffuse pain, fatigue, sleep impairment, and cognitive dysfunction, is associated with significant functional disability. Central sensitization can occur as an immediate or delayed phenomenon [ 38 ], resulting in increased sensitivity of wide dynamic range and nociception specific neurons of the spinal cord. Quality assurance and quality control of the microarray data were confirmed by examining outliers from the histograms of the microarray data generated.
Light-microscopical and histochemical findings.
But you have to take gabapentin three or four times a day, which makes it less convenient than pregabalin, taken in two daily doses. Amazingly, I ended up having my strongest workout of the week! Author Contribution N. I convinced my rheumatologist to bump me up to Tylenol 4, which helped.
International Review of Neurobiology.